3 They also inhibit the production of estrogen through reversible binding to the aromatase enzyme heme-iron component. 2 They inhibit estrogen synthesis through reversible aromatase enzyme competition. The second type is referred to as a non-steroidal inhibitors (for example, anastrozole). 3 This type is known as an irreversible steroidal inhibitors. 2 The first type produces a permanent bond with the aromatase enzyme, which leads to permanent inactivation of the enzyme. There are 2 main types of aromatase inhibitors, which are known to block aromatase action, which consequently results in a reduced estrogen production. 1 The inhibitor suppresses the activity of aromatase enzymes, which is responsible for the production of estrogen from androgens under normal circumstances. Aromatase inhibitors play an important role in estrogen receptor (ER)-positive breast cancer therapy in postmenopausal women.
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